1de·spair 
/dɪˈspeɚ/ noun
/dɪˈspeɚ/ noun [noncount] 1 : the feeling of no longer having any hope
▪ His despair nearly drove him mad. ▪ She let out a cry of despair. [=desperation] ▪ I was overcome by despair at being unable to find them. ▪ She finally gave up in despair. ▪ The people were driven to despair by the horrors of war. ▪ This latest setback has brought/carried/driven her to the depths of despair. 2 : someone or something that causes extreme sadness or worry — + of ▪ He was the despair of his parents.
▪ His despair nearly drove him mad. ▪ She let out a cry of despair. [=desperation] ▪ I was overcome by despair at being unable to find them. ▪ She finally gave up in despair. ▪ The people were driven to despair by the horrors of war. ▪ This latest setback has brought/carried/driven her to the depths of despair.
